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1st Incubation 5 hrs, 2nd incubation 10 min

Detection Target name
Rat Leptin

Target Synonyms
Leptin, Obesity factor

Description
Leptin, which is a product of ob gene, is a protein consisting of 167 amino acids and it is secreted from white adipose tissue. It is known that leptin acts on hypothalamus to decrease food intake and to reduce body weight, body fat, blood sugar and blood insulin in a healthy and an ob/ob mouse. Further, gene expression of neuropeptide Y(NPY) is surpressed by leptin. Recently, radioimmunoassay for leptin determination in human plasma has become available and leptin level in human patient group with obesity was found to increase in comparison with that of normal group. The level well correlate with body fat and these observations show clearly that leptin concentration in human plasma reflects the tissue fat weight. The measurement of plasma leptin may be an excellent index of obesity. Although rat leptin shows a high homology (96%) with mouse leptin, it is observed that substitution of several amino acid residues occurs at both end N- and C- terminal region between human and rat leptin. These findings have required urgently to develop highly sensitive immunoassay system specific to rat leptin. Yanaihara Insutitute Inc. has developed the enzyme immunoassay (EIA) kit which is a stable and convenient assay system for rat leptin in its plasma, serum and culture supernatant.

This product is useful for Diabetes / Obesity study.

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