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1st Incubation 3 hrs, 2nd incubation 2 hrs, 3rd incubation 1 hr, 4th incubation 30 min

Detection Target name
Mouse Leptin

Target Synonyms
Leptin, Obesity factor

Description
Leptin, which is a product of ob gene, is a protein consisting of 146 amino acids and it is secreted from white adipose tissue. It is known that leptin acts on hypothalamus to decrease food intake and reduce body weight, body fat, blood sugar and blood insulin in a healthy and an ob/ob mice. Further, gene expression of neuropeptide Y (NPY) is suppressed by this protein. Recently, radioimmunoassay for leptin determination in human plasma has become available and leptin level in human patient group with obesity was found to increase in comparison with that in normal group. The plasma level well correlated with body fat and these observations showed clearly that leptin concentration in human plasma reflects tissue fat weight. The measurement of leptin in plasma or serum may be a good index of obesity. Although mouse leptin shows a high homology (96%) with rat leptin in amino acid sequences, it is observed that substitution of quite a number of residues occurs between human and mouse leptin. These findings have urged us to develop highly sensitive immunoassay system specific to rat or mouse leptin. Yanaihara Institute Inc. already has rat leptin ELISA kit (YK050 and YK051), and now we have developed mouse leptin ELISA kit for measuring mouse leptin in its serum. It will be a specifically useful tool for leptin researches.

This product is useful for Diabetes / Obesity study.

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Immuno Assays

YK050 Rat Leptin ELISA Kit

YK051 Rat Leptin-HS ELISA Kit

Antibodies

YC040 Leptin (Rat)