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1st Incubation 16-18 hrs, 2nd incubation 1 hr, 3rd incubation 30 min

Detection Target name
Rat Glicentin

Target Synonyms
Glicentin

Description
Glicentin is a 69-amino-acid peptide containing glucagon and oxyntomodulin sequences in the molecule. It is suggested that glicentin and oxyntomodulin are produced in the intestinal L-cells and glucagon in A-cells in the pancreas, these peptides are derived from a common precursor by two different tissue-specific processing pathways. In 1983, the amino acid sequence of human glicentin was deduced by Bell et al. from the genomic sequence of human preproglucagon. Glicentin is a major form of gut glucagon-like immunoreactants (Gut GLIs). In mammalian small intestine, proglucagon is processed into glicentin, oxyntomodulin, and glucagon ?like peptide (GLP)-1 and ?2. GLP-1(7-37) and GLP-1(7-36) amide have been isolated from the intestine and pancreas. It has been known that the GLP-1 sequence is well conserved between species in all mammals studied. Using synthetic peptides, several investigators have demonstrated that in contrast to GLP-1(1-37), truncated GLP-1(7-36) amide and GLP-1(7-37) have several physiological effects. However, the physiological role of glicentin, a major gut glucagon, is still unclear. It has been known that the circulating level of plasma glicentin-like peptides increases significantly nutrient ingestion. Yanaihara institute Inc. has succeeded in developing a specific and convenient EIA kit for determination of rat glicentin in plasma.

This product is useful for Diabetes / Obesity study.

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Antibodies

Y324 Glicentin (1-32) (Rat)