| Note | Detection Target name
Human ｃ-Met
Target Synonyms
ｃ-Met, c-met, Hepatocyte growth factor receptor, Short name=HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, MET
Description
c-Met, the product of c-met gene has been reported to be the HGF receptor since HGF induces phosphorylation of c-Met by binding specifically to it. It is a heterodimer protein composed of an alpha-chain that is linked to a beta-chain. The beta-chain has the intracellular tyrosine kinase domain, the transmembrane domain and the extracellular domain, and it is tied into the alpha-chain that is the extracellular domain of c-Met. c-Met exists mainly in epidermal cells. It is found in the digestive tract, prostate gland, seminal vesicles, mammary gland, microglia cells, monocytes and macrophages, and more amount in the liver and kidney. It is considered that c-Met tansmits signals resulting from binding to HGF, such as growth, motility and organ formation, in the organs and cells mentioned above. This kit is designed to measure Human c-Met. This product is useful for Gastroenterology study. |
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