Home » Products » Reagents / Proteins » 01-511 Cholera toxin from Vibrio Cholerae
- 01-511
- Cholera toxin from Vibrio Cholerae
| Format | 1.0 mg/ml in 50 mM Tris-HCl (pH7.5) 0.2 M NaCl 1mM Na2EDTA 10% Glycerol |
|---|---|
| Storage | -70℃ |
| Package | 100ug |
| Download (protocol) | protocol |
| Note | Species origin Vibrio Cholerae Molecule Name Cholera toxin Type (General) peptide/protein Full Description The main enterotoxin, known as cholera toxin, interacts with G proteins and increases cyclic AMP in the intestinal lining to open ion channels . As ions flow into the intestinal lumen (lining), body fluids (mostly water) flows out of the body due to osmosis leading to massive diarrhea as the fluid is expelled from the body.. Cholerae toxin is a complex consisting of one molecule of A subunit (27.2 kD) and 5 molecules of B subunit (11.6 kD). It adsorbs to GM1 ganglioside on the surface of target cells by the B subunit and penetrates into cells where A subunit is dissociated and processed into A1, which constitutively activates adenyl cyclase activity of .subunit of Gs (a kind of GTP-binding protein). This toxin was highly purified from growth medium of Vibrio cholerae 569B strain. |
