Home » Products » Reagents / Proteins » 01-517 Diphtheria toxin
- 01-517
- Diphtheria toxin
| Format | 5 mg/ml in 20 mM Tris-HCl (pH 7.2) 150 mM NaCl |
|---|---|
| Storage | -70℃ |
| Package | 200ug |
| Download (protocol) | protocol |
| Note | Species origin Diphtheria toxin Molecule Name Diphtheria toxin Type (General) peptide/protein Full Description This Diphtheria toxin was highly purified from growth media as an exotoxin secreted by Corynebacterium diphtheriae strain PW8. Diphtheria toxin is a single polypeptide chain of 535 amino acids (58 kD) consisting of two subunits linked by disulfide bridges . Binding to the cell surface of the less stable of these two subunits allows the more stable part of the protein to penetrate the host cell. It catalyzes the ADP-ribosylation eucaryotic elongation factor-2 (eEF2) by using NAD, thus inactivating this protein. It does so by ADP-ribosylating the unusual aminoacid diphthamide . In this way, it acts as an inhibitor of protein synthesis. |
